Perhaps K-12 science teachers may have missed Bill Gate’s thoughts that include Tablet PCs in future scientific research when it was posted earlier. Salvatore Salamone of Bio-IT World reviews Bill Gates’ keynote address at SC05 about how innovations in high-performance computing (HPC) will improve collaboration and speed research developments by connecting scientists, computing resources, and data. Gates noted that several industry megatrends are coming together to alter the way research is conducted. These include increased processing power of HPC systems, service-oriented architectures that make it easier to share and access data, new computer form factors (Tablet PCs, PDAs, cell phones, etc.) that help collect data, and the digitalization of product design and simulation.